TY  - JOUR
AU  - Huang, Zhuoqi
AU  - Ma, Rui
AU  - Xiao, Zhen
AU  - Zhou, Xuemeng
TI  - Epigenetic dysregulation of gastrointestinal tumors
JO  - Journal of Translational Genetics and Genomics
PY  - 2026
VL  - 10
IS  - 3
SP  - 448
EP  - 67
SN  - ISSN 2578-5281 (Online)
AB  - <p>Gastrointestinal cancers mainly include esophageal cancer, gastric cancer, and colorectal cancer. These tumor types account for a huge number of new cases and deaths across the world. Although numerous genetic studies have shown the importance of gene mutations in their pathology, they are still insufficient to capture all layers of cancer development. Recently, epigenetic dysregulation has drawn attention because of its potential in the diagnosis and treatment of gastrointestinal cancers. Among diverse epigenetic pathways, DNA methylation is the best-studied and has displayed clinical value. Additionally, research on histone modifications, chromatin remodeling and RNA-mediated regulation is rapidly accumulating. In this review, we systematically illustrate the epigenetic dysregulation in gastrointestinal cancers to provide hints for clinical transformation.</p>
KW  - Epigenetic regulation
KW  - DNA methylation
KW  - esophageal cancer
KW  - gastric cancer
KW  - colorectal cancer
DO  - 10.20517/jtgg.2026.68
UR  - https://dx.doi.org/10.20517/jtgg.2026.68