TY  - JOUR
AU  - Ge, Lingqiao
AU  - Fang, Xiangdong
TI  - Advances in multidimensional risk factors and comorbidities of gout based on UK Biobank data
JO  - Journal of Translational Genetics and Genomics
PY  - 2026
VL  - 10
IS  - 3
SP  - 497
EP  - 517
SN  - ISSN 2578-5281 (Online)
AB  - <p>Gout is an increasingly prevalent inflammatory arthritis that substantially affects quality of life and contributes to a growing public health burden. Understanding its complex network of risk factors is crucial for effective prevention and management. The emergence of large-scale cohorts, particularly the UK Biobank, has facilitated etiologic, genetic, and clinical research on gout and related urate phenotypes. By providing multidimensional lifestyle, clinical, and omics data, the UK Biobank serves as a powerful resource for dissecting the multifaceted nature of gout. Here, we provide a critical narrative review of UK Biobank-based gout research, focusing on multidimensional determinants, convergent and conflicting evidence, comorbidity networks, clinical implications, and methodological limitations and potential biases. This review aims to provide an evidence-based framework for informing gout prevention, comorbidity assessment, and future research.</p>
KW  - Gout
KW  - UK Biobank
KW  - risk factors
KW  - epidemiology
DO  - 10.20517/jtgg.2026.12
UR  - https://dx.doi.org/10.20517/jtgg.2026.12