TY - JOUR TI - The role of noncoding RNA in aortic dissection JO - Vessel Plus PY - 2026 VL - 10 IS - 2 SP - EP - 28 SN - ISSN 2574-1209 (Online) AB -

Aortic dissection (AD) is a rapidly progressive cardiovascular disease associated with high mortality. The core pathogenic mechanisms of AD include apoptosis and phenotypic switching of vascular smooth muscle cells (VSMCs), remodeling and degradation of the extracellular matrix (ECM), and vascular inflammation. However, the detailed molecular mechanisms remain incompletely understood. Noncoding RNAs (ncRNAs) are RNA molecules that do not encode proteins. Recent studies have confirmed that ncRNAs with aberrant expression exert critical regulatory functions in the pathogenesis and progression of AD, and several ncRNAs have shown significant application potential in the early diagnosis, conservative treatment, and prognostic assessment of AD. This review summarizes the latest research progress on the regulatory mechanisms of various ncRNAs in AD, and critically evaluates their potential clinical utility as clinical biomarkers and therapeutic targets for AD.

KW - Aortic dissection KW - vascular smooth muscle KW - extracellular matrix KW - inflammation KW - noncoding RNA DO - 10.20517/2574-1209.2025.144 UR - https://dx.doi.org/10.20517/2574-1209.2025.144